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PMID: 6218859 Published · ppublish English Journal Article

Identification of adverse reactions to new drugs. II--How were 18 important adverse reactions discovered and with what delays?

British medical journal (Clinical research ed.) ·Vol. 286 ·No. 6361 ·1983-01-22 ·Pages 289-92

Venning GR

Abstract

The process of discovery of 18 important adverse drug reactions was reviewed. For each adverse reaction the dates were noted of the report which first alerted the medical profession to the suspected reaction, the report which resulted in verification of causality beyond reasonable doubt, and the first regulatory action or warning to the medical profession in Britain by the Committee on the Safety of Medicines.

MeSH Terms
Chloramphenicol/adverse effects Clioquinol/adverse effects Contraceptives, Oral/adverse effects Diethylstilbestrol/adverse effects Drug and Narcotic Control Drug-Related Side Effects and Adverse Reactions Halothane/adverse effects Humans Methysergide/adverse effects Phenacetin/adverse effects Phenformin/adverse effects Practolol/adverse effects Sympathomimetics/adverse effects Time Factors United Kingdom
Chemicals
Contraceptives, Oral Sympathomimetics Chloramphenicol Diethylstilbestrol Clioquinol Phenformin Phenacetin Practolol Halothane Methysergide
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Venning G R
References (36)
36 references, click to expand
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Article Info
Journal
British medical journal (Clinical research ed.)
Abbr.
Br Med J (Clin Res Ed)
ISSN
0267-0623
DOI
10.1136/bmj.286.6361.289
Published
1983-01-22
Pages
289-92
Language
English
Region
England
NLM ID
8302911
PMCID
PMC1546494
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.286.6361.289 PMC Full Text
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