High-performance liquid chromatography of pefloxacin and its main active metabolites in biological fluids.

Journal of chromatography ·Vol. 272 ·No. 2 ·1983-02-11 ·Pages 359-65

Montay G, Blain Y, Roquet F, Le Hir A

Abstract

We describe a high-performance liquid chromatographic (HPLC) method for the analysis of pefloxacin, a new antibacterial agent, in plasma and urine following administration of a therapeutic dose in humans. HPLC assay of pefloxacin and its two main active metabolites in urine is also described. The applicability of the methods to pharmacokinetic studies of pefloxacin in humans is demonstrated.

MeSH Terms

Anti-Infective Agents Chromatography, High Pressure Liquid/methods Humans Nalidixic Acid/analogs & derivatives,blood,metabolism,urine Norfloxacin Pefloxacin Time Factors

Chemicals

Anti-Infective Agents Pefloxacin Nalidixic Acid oxonorfloxacin Norfloxacin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Montay G

Blain Y

Roquet F

Le Hir A

Article Info

Journal

Journal of chromatography

Abbr.

J Chromatogr

DOI

10.1016/s0378-4347(00)86139-3

Published

1983-02-11

Pages

359-65

Language

English

Region

Netherlands

NLM ID

0427043

Subset

External Links

PubMed source DOI: 10.1016/s0378-4347(00)86139-3

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High-performance liquid chromatography of pefloxacin and its main active metabolites in biological fluids.

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