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PMID: 6220974 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Role of the major histocompatibility complex in resistance and granuloma formation in response to Mycobacterium lepraemurium infection.

Infection and immunity ·Vol. 40 ·No. 2 ·1983-05-00 ·Pages 720-5

Adu HO, Curtis J, Turk JL

Abstract

Resistance to a subcutaneous infection with a moderate dose of Mycobacterium lepraemurium was investigated in C57BL/6 mice and in three congenic strains with the BALB background (BALB/c, BALB/B, and BALB/K). Resistance after 10 weeks of infection was found not to be linked to the major histocompatibility complex. The ability to develop a delayed hypersensitivity response to an ultrasonicate of M. lepraemurium was associated with the background genes, and this ability had no influence on resistance to M. lepraemurium. Granuloma formation at the infection site in the early stages appeared to be linked to the H-2b haplotype. The types of cells involved in the granulomas were also investigated.

MeSH Terms
Animals Female Granuloma/immunology Hypersensitivity, Delayed/immunology Major Histocompatibility Complex Mice Mycobacterium Infections/immunology,pathology Mycobacterium lepraemurium/immunology Skin Tests T-Lymphocytes, Regulatory/immunology Time Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Adu H O
Curtis J
Turk J L
References (17)
17 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.40.2.720-725.1983
Published
1983-05-00
Pages
720-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC264915
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.40.2.720-725.1983 PMC Full Text View journal details
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