Comparative activities of norfloxacin and fifteen other antipseudomonal agents against gentamicin-susceptible and -resistant Pseudomonas aeruginosa strains.

Antimicrobial agents and chemotherapy ·Vol. 24 ·No. 4 ·1983-10-00 ·Pages 602-4

Forward KR, Harding GK, Gray GJ, Urias BA, Ronald AR

Abstract

We compared the activity of norfloxacin (MK-0366), a new orally absorbable derivative of naladixic acid, with those of other antipseudomonal agents against Pseudomonas aeruginosa. Norfloxacin was the most active against both gentamicin-susceptible and gentamicin-resistant strains, having 90% minimal inhibitory concentrations of 2 and 8 micrograms/ml, respectively. This excellent in vitro activity may make norfloxacin effective for oral therapy of P. aeruginosa urinary tract infections.

MeSH Terms

Anti-Bacterial Agents/pharmacology Drug Resistance, Microbial Gentamicins/pharmacology Microbial Sensitivity Tests Nalidixic Acid/analogs & derivatives,pharmacology Norfloxacin Pseudomonas aeruginosa/drug effects

Chemicals

Anti-Bacterial Agents Gentamicins Nalidixic Acid Norfloxacin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Forward K R

Harding G K

Gray G J

Urias B A

Ronald A R

References (6)

6 references, click to expand

Carbenicillin resistance in Pseudomonas aeruginosa from clinical material.
Br Med J. 1969 Jul 19;3(5663):141-3 PMID: 4978352
In vitro activity of MK-0366 against clinical urinary pathogens including gentamicin-resistant Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 1982 Apr;21(4):670-2 PMID: 6211142
Determination of norfloxacin, a new nalidixic acid analog, in human serum and urine by high-performance liquid chromatography.
Antimicrob Agents Chemother. 1982 May;21(5):808-10 PMID: 6213199
Comparative in vitro activity of norfloxacin (MK-0366) and ten other oral antimicrobial agents against urinary bacterial isolates.
Antimicrob Agents Chemother. 1982 May;21(5):848-51 PMID: 6213200
Norfloxacin and the antibacterial gamma pyridone beta carboxylic acids.
J Antimicrob Chemother. 1982 Jul;10(1):25-30 PMID: 6213593
Antibacterial activity of norfloxacin.
Antimicrob Agents Chemother. 1983 Jan;23(1):15-8 PMID: 6219617

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.24.4.602

Published

1983-10-00

Pages

602-4

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC185382

Subset

External Links

PubMed source DOI: 10.1128/AAC.24.4.602 PMC Full Text View journal details

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Comparative activities of norfloxacin and fifteen other antipseudomonal agents against gentamicin-susceptible and -resistant Pseudomonas aeruginosa strains.

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