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PMID: 6232084 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Norfloxacin (MK-0366, AM-715): in vitro activity and cross-resistance with other organic acids including quality control limits for disk diffusion testing.

Diagnostic microbiology and infectious disease ·Vol. 1 ·No. 2 ·1983-06-00 ·Pages 165-72

Jones RN, Barry AL

Abstract

Norfloxacin is a new organic acid antimicrobic with an expanded spectrum that includes Staphylococcus spp, most Pseudomonas spp, Acinetobacter calcoaceticus ssp anitratus, some streptococci, as well as nearly all enteric bacilli. The drug appears to be bactericidal. Its expanded spectrum suggests that it should be tested separately by disk diffusion or other susceptibility testing methods. Tentative norfloxacin disk test quality control limits were derived from the results of a multi-laboratory study: Escherichia coli, 28-36 mm; S. aureus, 17-28 mm, and Pseudomonas aeruginosa, 22-29 mm.

MeSH Terms

Acinetobacter/drug effects Anti-Infective Agents, Urinary/pharmacology Bacteria/drug effects Cinoxacin/pharmacology Drug Combinations/pharmacology Drug Resistance, Microbial Enterobacteriaceae/drug effects Enterococcus faecalis/drug effects Escherichia coli/drug effects Microbial Sensitivity Tests/standards Nalidixic Acid/analogs & derivatives,pharmacology Norfloxacin Oxolinic Acid/pharmacology Pseudomonas/drug effects Pseudomonas aeruginosa/drug effects Quality Control Reference Standards Staphylococcus aureus/drug effects Sulfamethoxazole/pharmacology Trimethoprim/pharmacology Trimethoprim, Sulfamethoxazole Drug Combination

Chemicals

Anti-Infective Agents, Urinary Drug Combinations Nalidixic Acid Trimethoprim, Sulfamethoxazole Drug Combination Trimethoprim Sulfamethoxazole Oxolinic Acid Cinoxacin Norfloxacin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Jones R N

Barry A L

Article Info

Journal

Diagnostic microbiology and infectious disease

Abbr.

Diagn Microbiol Infect Dis

ISSN

0732-8893

DOI

10.1016/0732-8893(83)90047-0

Published

1983-06-00

Pages

165-72

Language

English

Region

United States

NLM ID

8305899

Subset

External Links

PubMed source DOI: 10.1016/0732-8893(83)90047-0 View journal details

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Norfloxacin (MK-0366, AM-715): in vitro activity and cross-resistance with other organic acids including quality control limits for disk diffusion testing.

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