Home LiteratureArticle Details
PMID: 6236745 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Recovery of norfloxacin in feces after administration of a single oral dose to human volunteers.

Antimicrobial agents and chemotherapy ·Vol. 26 ·No. 1 ·1984-07-00 ·Pages 110-1

Cofsky RD, duBouchet L, Landesman SH

Abstract

Twelve healthy volunteers received single 400-mg oral doses of norfloxacin. During the ensuing 48 h, from 8.3 to 53.3% (mean, 28%) of this dose was recovered in the feces. Peak drug concentrations in fecal specimens ranged from 207 to 2,716 micrograms/g.

MeSH Terms
Adult Feces/analysis Humans Male Middle Aged Nalidixic Acid/analogs & derivatives,metabolism Norfloxacin Time Factors
Chemicals
Nalidixic Acid Norfloxacin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cofsky R D
duBouchet L
Landesman S H
References (5)
5 references, click to expand
  1. Comparative in vitro activity of norfloxacin (MK-0366) and ten other oral antimicrobial agents against urinary bacterial isolates.
    Antimicrob Agents Chemother. 1982 May;21(5):848-51 PMID: 6213200
  2. In vitro antibacterial activity of norfloxacin (MK-0366).
    Antimicrob Agents Chemother. 1982 Apr;21(4):604-7 PMID: 6211139
  3. In vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim.
    Antimicrob Agents Chemother. 1982 Jul;22(1):23-7 PMID: 6214995
  4. In vitro antibacterial activity of norfloxacin (MK-0366, AM-715) and other agents against gastrointestinal tract pathogens.
    Antimicrob Agents Chemother. 1983 Jan;23(1):86-90 PMID: 6219622
  5. Antibacterial activity of norfloxacin.
    Antimicrob Agents Chemother. 1983 Jan;23(1):15-8 PMID: 6219617
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.26.1.110
Published
1984-07-00
Pages
110-1
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC179930
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.26.1.110 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2