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PMID: 6237606 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

In vitro activities of teichomycin, fusidic acid, flucloxacillin, fosfomycin, and vancomycin against methicillin-resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 26 ·No. 2 ·1984-08-00 ·Pages 268-9

Guenthner SH, Wenzel RP

Abstract

Flucloxacillin, fosfomycin, fusidic acid, teichomycin, and vancomycin were tested against 50 clinical isolates of methicillin-resistant Staphylococcus aureus by a broth macrodilution technique. Teichomycin had a narrow range of activity, similar to that of vancomycin (0.5 to 2.0 micrograms/ml). Fusidic acid had the lowest range of inhibitory activity, with 50 and 90% MICs of 0.19 and 0.35 micrograms/ml, respectively. Flucloxacillin and fosfomycin showed less activity, with MICs up to 32 micrograms/ml.

MeSH Terms
Anti-Bacterial Agents/pharmacology Floxacillin/pharmacology Fosfomycin/pharmacology Fusidic Acid/pharmacology Glycopeptides/pharmacology Methicillin/pharmacology Microbial Sensitivity Tests Penicillin Resistance Staphylococcus aureus/drug effects Teicoplanin Vancomycin/pharmacology
Chemicals
Anti-Bacterial Agents Glycopeptides Fosfomycin Floxacillin Fusidic Acid Teicoplanin Vancomycin Methicillin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Guenthner S H
Wenzel R P
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20 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.26.2.268
Published
1984-08-00
Pages
268-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC284135
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.26.2.268 PMC Full Text View journal details
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