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PMID: 6237981 Published · ppublish English Journal Article

One-way occurrence of graft-versus-host disease in bone marrow chimaeras between congenic MRL mice.

Immunology ·Vol. 53 ·No. 2 ·1984-10-00 ·Pages 251-6

Fujiwara M, Kariyone A

Abstract

Bone marrow cells (BMCs) of MRL/Mp-lpr/lpr (MRL/l) mice, when infused into irradiated MRL/Mp-+/+ (MRL/n) mice, induced graft-versus-host disease (GVHD) and recipients died of wasting syndromes beginning around a few weeks later. Protracted appearance of GVHD was observed when (MRL/n X MRL/l) F1 mice were used as recipients of MRL/l BMSs. On the other hand, MRL/n BMCs did not elicit GVHD in irradiated MRL/l mice. Treatment of MRL/l BMCs with anti-Thy-l antiserum plus complement did not eliminate GVHD-provoking capacity. Thymectomy of the recipents reduced the incidence of GVHD. No apparent reaction was observed in mutual mixed lymphocyte culture of spleen cells from MRL/l and MRL/n mice. These data suggest that injected T cell precursors of MRL/l mice become mature through the host (MRL/n mice) thymus and appear in the periphery as functioning T cells, resulting in the appearance of GVHD.

MeSH Terms
Animals Bone Marrow Transplantation Graft vs Host Disease/etiology,immunology,mortality,pathology Lymphocyte Culture Test, Mixed Mice Mice, Inbred Strains Radiation Chimera Spleen/pathology Thymectomy
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fujiwara M
Kariyone A
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22 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1984-10-00
Pages
251-6
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1454822
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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