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PMID: 6242706 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin/thromboxane A2 system.

Clinical & experimental metastasis ·Vol. 1 ·No. 2 ·1983-00-00 ·Pages 103-14

Honn KV

Abstract

The interaction between metastasizing tumor cells and the hemostatic system of the host has been implicated in successful tumor cell dissemination. Prostacyclin (PGI2) decreases metastasis from tail vein injected B16 amelanotic melanoma (B16a) cells when administered 15 min prior to tumor cells. This effect is potentiated by a phosphodiesterase inhibitor. Initial trapping of 125I Udr labelled tumor cells in pulmonary vascular beds is unaltered by PGI2 but retention time is decreased. PGI2 decreases retention time even when administered 60 min post tumor cells. Structurally unrelated thromboxane (TX) synthetase inhibitors and a TXA2 receptor antagonist also reduce metastasis from tail vein injected B16a cells. Furthermore, one inhibitor, 1-(7-carboxyheptyl)imidazole, when injected intraperitoneally reduced spontaneous metastasis from subcutaneous B16a and Lewis lung carcinoma tumors. These results suggest that selective manipulation of PGI2 and TXA2 can reduce the hematogenous spread of tumor cells.

MeSH Terms
6-Ketoprostaglandin F1 alpha/pharmacology Animals Carcinoma/physiopathology Dose-Response Relationship, Drug Epoprostenol/pharmacology,physiology Female Imidazoles/pharmacology Lung Neoplasms/physiopathology Male Melanoma/physiopathology Mice Mice, Inbred C57BL Neoplasm Metastasis/physiopathology Neoplasm Seeding Pregnancy Receptors, Prostaglandin/pharmacology Receptors, Thromboxane Theophylline/pharmacology Thromboxane A2/pharmacology,physiology Thromboxane-A Synthase/pharmacology
Chemicals
Imidazoles Receptors, Prostaglandin Receptors, Thromboxane Thromboxane A2 6-Ketoprostaglandin F1 alpha 1-carboxyheptylimidazole Theophylline Epoprostenol Thromboxane-A Synthase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Honn K V
References (38)
38 references, click to expand
  1. 9,11-epoxyiminoprosta-5,13-dienoic acid is a thromboxane A2 antagonist in human platelets.
    Nature. 1978 Oct 26;275(5682):764-6 PMID: 703845
  2. Inhibition of the platelet-aggregating activity of two human adenocarcinomas of the colon and an anaplastic murine tumor with a specific thrombin inhibitor, dansylarginine N-(3-ethyl-1,5-pentanediyl)amide.
    Cancer Res. 1981 Nov;41(11 Pt 1):4535-9 PMID: 7306974
  3. Mechanisms of metastasis.
    Biochim Biophys Acta. 1979 Feb 4;560(1):135-66 PMID: 367443
  4. Decreased vascular prostacyclin (PGI2) in diabetic rats. Stimulation of PGI2 release in normal and diabetic rats by the antithrombotic compound Bay g 6575.
    Thromb Res. 1980 Aug 15-Sep 1;19(4-5):663-70 PMID: 7003804
  5. Stimulation of prostacyclin release from vessel wall by Bay g 6575, an antithrombotic compound.
    Lancet. 1979 Mar 10;1(8115):518-20 PMID: 85106
  6. Platelet and fibrinogen consumption in man.
    N Engl J Med. 1972 Nov 16;287(20):999-1005 PMID: 4675535
  7. Studies on mechanisms involved in metastasis formation from circulating tumor cells. Factors influencing tumor cell lodgement during normal and post-traumatic conditions.
    J Cancer Res Clin Oncol. 1980;97(3):249-56 PMID: 7440626
  8. A factor X-activating cysteine protease from malignant tissue.
    J Clin Invest. 1981 Jun;67(6):1665-71 PMID: 7016920
  9. A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors.
    Biochim Biophys Acta. 1978 Mar 1;539(2):162-72 PMID: 629996
  10. Increasing the efficiency of cancer chemotherapy with heparin: "clinical study".
    J Surg Oncol. 1973;5(2):189-93 PMID: 4703845
  11. Prostacyclin: a potent antimetastatic agent.
    Science. 1981 Jun 12;212(4500):1270-2 PMID: 7015512
  12. Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease.
    Int J Cancer. 1973 May;11(3):704-18 PMID: 4801854
  13. 9,11-Iminoepoxyprosta-5,13-dienoic acid is a selective thromboxane A2 synthetase inhibitor.
    Biochim Biophys Acta. 1979 May 25;573(2):238-44 PMID: 375987
  14. The inhibitory effect of heparin and warfarin treatments on the intravascular survival of B16 melanoma cells in syngeneic C57 mice.
    Cell Biol Int Rep. 1978 Jan;2(1):81-6 PMID: 630615
  15. Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line.
    Proc Natl Acad Sci U S A. 1980 Jul;77(7):4336-9 PMID: 6933486
  16. Plasma requirement for the aggregation of rabbit platelets by an aggregating material derived from SV40-transformed 3T3 fibroblasts.
    J Lab Clin Med. 1980 Dec;96(6):994-1001 PMID: 6253581
  17. Present concepts on the mechanisms of platelet aggregation.
    Biochem Pharmacol. 1981 Feb 15;30(4):263-71 PMID: 7011325
  18. The adhesion of thromboplastic tumour emboli to vessel walls in vivo.
    Br J Exp Pathol. 1972 Jun;53(3):301-13 PMID: 5055714
  19. Microangiopathic haemolytic anaemia and mucin-forming adenocarcinoma.
    Br J Haematol. 1970 Feb;18(2):183-93 PMID: 5439525
  20. Lysosomal cathepsin B: correlation with metastatic potential.
    Science. 1981 Jun 5;212(4499):1151-3 PMID: 7233209
  21. Platelet-cancer cell interaction in metastasis formation: a possible therapeutic approcach to metastasis prophylaxis.
    J Med. 1977;8(2):103-14 PMID: 268396
  22. Interactions of tumor cells with vascular endothelial cell monolayers: a model for metastatic invasion.
    Proc Natl Acad Sci U S A. 1979 Nov;76(11):5704-8 PMID: 293673
  23. Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes.
    Biochim Biophys Acta. 1978 Mar 14;523(1):250-62 PMID: 415760
  24. Albumin stabilizes thromboxane A2.
    FEBS Lett. 1977 Oct 15;82(2):321-4 PMID: 913605
  25. The prostanoids in hemostasis and thrombosis: a review.
    Am J Pathol. 1980 Jun;99(3):743-804 PMID: 6992594
  26. Evidence that cells from experimental tumours can activate coagulation factor X.
    Br J Cancer. 1979 Aug;40(2):228-33 PMID: 573131
  27. Selective inhibition of prostaglandin endoperoxide thromboxane isomerase by 1-carboxyalkylimidazoles.
    Prostaglandins. 1978 Oct;16(4):529-40 PMID: 725083
  28. A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase.
    Blood. 1979 Jun;53(6):1191-6 PMID: 376000
  29. Rationale and experimental design for the VA Cooperative Study of Anticoagulation (Warfarin) in the Treatment of Cancer.
    Cancer. 1979 Aug;44(2):732-41 PMID: 383261
  30. Aggregation of platelets and cell membrane vesiculation by rat cells transformed in vitro by Rous sarcoma virus.
    Cancer Res. 1978 Sep;38(9):2950-5 PMID: 209891
  31. Idiosyncratic platelet responses to human tumour cells.
    Nature. 1981 Jun 25;291(5817):661-2 PMID: 6264316
  32. The antithrombotic activity of BAY g 6575.
    Arzneimittelforschung. 1979;29(1):54-9 PMID: 375948
  33. Platelet aggregating material in mouse tumor cells. Removal and regeneration.
    Lab Invest. 1977 Apr;36(4):413-9 PMID: 191695
  34. Cancer procoagulant A: a factor X activating procoagulant from malignant tissue.
    Thromb Res. 1975 Feb;6(2):127-37 PMID: 234638
  35. Anticoagulants and experimental metastases-evaluation of antimetastatic effects in different model systems.
    J Cancer Res Clin Oncol. 1981;101(3):275-83 PMID: 7309780
  36. Antimetastatic effects associated with platelet reduction.
    Proc Natl Acad Sci U S A. 1968 Sep;61(1):46-52 PMID: 5246932
  37. Malignancy and haemostasis.
    Br J Haematol. 1980 Feb;44(2):173-82 PMID: 6990959
  38. Tumor shedding and coagulation.
    Science. 1981 May 22;212(4497):923-4 PMID: 7195067
Article Info
Journal
Clinical & experimental metastasis
Abbr.
Clin Exp Metastasis
ISSN
0262-0898
DOI
10.1007/BF00121490
Published
1983-00-00
Pages
103-14
Language
English
Region
Netherlands
NLM ID
8409970
Subset
IM
Grants
NCI NIH HHS · CA 29997 · United States
NCI NIH HHS · CA29405 · United States
External Links
PubMed source DOI: 10.1007/BF00121490 View journal details
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