Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.

3',5'-Cyclic-AMP Phosphodiesterases/metabolism Animals Carboxy-Lyases/biosynthesis Cyclooxygenase Inhibitors Female Indomethacin/pharmacology Mice Neoplasms, Experimental/prevention & control Ornithine Decarboxylase/biosynthesis Phorbols/antagonists & inhibitors Prostaglandins/metabolism Prostaglandins E, Synthetic/pharmacology Skin/drug effects,metabolism Skin Neoplasms/prevention & control Tetradecanoylphorbol Acetate/antagonists & inhibitors Tretinoin/antagonists & inhibitors

Cyclooxygenase Inhibitors Phorbols Prostaglandins Prostaglandins E, Synthetic Tretinoin 3',5'-Cyclic-AMP Phosphodiesterases Carboxy-Lyases Ornithine Decarboxylase Tetradecanoylphorbol Acetate Indomethacin