A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.

Alkylating Agents/chemical synthesis,pharmacology Animals Guinea Pigs In Vitro Techniques Morphinans/chemical synthesis,pharmacology Muscle Contraction/drug effects Muscle, Smooth/drug effects Naltrexone/analogs & derivatives Narcotic Antagonists/chemical synthesis Narcotics/chemical synthesis Oxymorphone/analogs & derivatives Receptors, Opioid/drug effects

Alkylating Agents Morphinans Narcotic Antagonists Narcotics Receptors, Opioid Naltrexone beta-funaltrexamine oxymorphone fumarate methyl ester Oxymorphone