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PMID: 6248877 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

In vitro construction of a B-tropic virus by recombination: B-tropism is a cryptic phenotype of xenotropic murine retroviruses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 5 ·1980-05-00 ·Pages 2989-93

Gautsch JW, Elder JH, Jensen FC, Lerner RA

Abstract

A B-tropic virus was isolated in vitro from the progeny of mouse cells doubly infected with N-tropic and xenotropic murine leukemia viruses. Biological and structural evidence is presented suggesting that the phenotypically silent structural marker for B-tropism, expressed by the xenotropic virus p30, was transferred to an N-ecotropic virus via recombination, thus resulting in the expression of a B-ecotropic murine leukemia virus.

MeSH Terms
Animals Cells, Cultured Glycoproteins/physiology Leukemia Virus, Murine/genetics,growth & development Mice Peptide Fragments/analysis Recombination, Genetic Viral Proteins/physiology Virus Replication
Chemicals
Glycoproteins Peptide Fragments Viral Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Gautsch J W
Elder J H
Jensen F C
Lerner R A
References (33)
33 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.5.2989
Published
1980-05-00
Pages
2989-93
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC349532
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.5.2989 PMC Full Text View journal details
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