In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strains.
Minimum inhibitory concentrations and agar disk diffusion tests were determined on clinical isolates of beta-lactamase-positive and beta-lactamase-negative Neisseria gonorrhoeae and Haemophilus influenzae with the newer beta-lactam antibiotics, cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and piperacillin, and with seven older beta-lactam antibiotics. All the drugs were active against beta-lactamase-negative strains of N. gonorrhoeae and H. influenzae. The drug most active against beta-lactamase-positive N. gonorrhoeae was cefotaxime, followed closely by cefoperazone, moxalactam, piperacillin, and mezlocillin. The drugs most active against beta-lactamase-positive strains of H. influenzae were cefotaxime, moxalactam, cefoperazone, and cefamandole.
16 references, click to expand
-
Antibiotic susceptibility of Neisseria gonorrhoeae strains from Europe and Africa.Antimicrob Agents Chemother. 1979 Apr;15(4):535-9 PMID: 111615
-
The in vitro activity of 15 penicillins and mecillinam against Neisseria gonorrhoeae.J Antimicrob Chemother. 1977 Jul;3(4):331-7 PMID: 197052
-
Cefuroxime, an in vitro Comparison with Six Other Cephalosporins.Proc R Soc Med. 1977;70(Suppl 9):63-71 PMID: 20919420
-
In vitro antimicrobial activity of piperacillin and seven other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase producing strains.J Antimicrob Chemother. 1979 Mar;5(2):137-42 PMID: 107152
-
Activity of azlocillin and mezlocillin against gram-negative organisms: comparison with other penicillins.Antimicrob Agents Chemother. 1978 Apr;13(4):559-65 PMID: 96726
-
Treatment of uncomplicated gonococcal urethritis with cefoxitin: comparison with penicillin.Rev Infect Dis. 1979 Jan-Feb;1(1):183-8 PMID: 400933
-
Susceptibility of ampicillin-resistant Haemophilus influenzae to seven penicillins.Antimicrob Agents Chemother. 1976 Jan;9(1):70-3 PMID: 1083202
-
beta-lactamase stability of HR 756, a novel cephalosporin, compared to that of cefuroxime and cefoxitin.Antimicrob Agents Chemother. 1978 Sep;14(3):322-6 PMID: 101128
-
Disc agar diffusion antimicrobial susceptibility tests with beta-lactamase producing Neisseria gonorrhoeae.J Antibiot (Tokyo). 1978 Apr;31(4):352-8 PMID: 96085
-
National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results.N Engl J Med. 1976 Jan 1;294(1):5-9 PMID: 127947
-
Ampicillin-resistant Haemophilus influenzae type B possessing a TEM-type beta-lactamase but little permeability barrier to ampicillin.Lancet. 1975 Mar 29;1(7909):716-9 PMID: 47483
-
Beta-lactamase-producing, penicillin-resistant gonococcus.Lancet. 1976 Sep 25;2(7987):656-7 PMID: 60518
-
Cefoperazone (T-1551), a new semisynthetic cephalosporin: comparison with cephalothin and gentamicin.Antimicrob Agents Chemother. 1980 Apr;17(4):743-9 PMID: 6446879
-
In vitro activity of HR 756, a new cephalosporin, against Neisseria gonorrhoeae.Antimicrob Agents Chemother. 1979 Mar;15(3):452-4 PMID: 111612
-
Penicillinase-producing Gonococci in Liverpool.Lancet. 1976 Dec 25;2(8000):1379-82 PMID: 63850
-
Letter: Ampicillin-resistant Haemophilus influenzae meningitis.Lancet. 1974 Feb 23;1(7852):313 PMID: 4130492
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