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PMID: 6251944 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Glial fibrillary acidic protein in monolayer cultures of C-6 glioma cells: effect of aging and dibutyryl cyclic AMP.

Brain research ·Vol. 200 ·No. 1 ·1980-10-27 ·Pages 225-30

Raju TR, Bignami A, Dahl D

Abstract

Aging induced a dramatic increase in the number of glial fibrillary acidic protein (GFA) positive cells in monolayer cultures of C-6 cells. Dibutyryl cyclic AMP (DBcAMP) had a similar effect on subconfluent cultures. Both aging and DBcAMP treatment also helped C-6 cells to develop mature astroglia like morphology.

MeSH Terms
Animals Bucladesine/pharmacology Cell Line Fluorescent Antibody Technique Glial Fibrillary Acidic Protein Glioma/metabolism Histocytochemistry Nerve Tissue Proteins/metabolism Rats Time Factors
Chemicals
Glial Fibrillary Acidic Protein Nerve Tissue Proteins Bucladesine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Raju T R
Bignami A
Dahl D
Article Info
Journal
Brain research
Abbr.
Brain Res
ISSN
0006-8993
DOI
10.1016/0006-8993(80)91114-2
Published
1980-10-27
Pages
225-30
Language
English
Region
Netherlands
NLM ID
0045503
Subset
IM
Grants
NINDS NIH HHS · NS13034 · United States
External Links
PubMed source DOI: 10.1016/0006-8993(80)91114-2 View journal details
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