Histone 2B can be modified by the attachment of ubiquitin.

Nucleic acids research ·Vol. 8 ·No. 20 ·1980-10-24 ·Pages 4671-80

West MH, Bonner WM

Abstract

Histone 2B in mouse and man can be modified by the post-translational addition of ubiquitin. In mouse L1210 cells, both H2B variants are modified, however only to the extent of 1-1.5% compared with about 11% of H2A. Analysis of cyanogen bromide peptides shows that ubiquitin is attached to the C-terminal part of the histone.

MeSH Terms

Animals Cell Nucleus/analysis Chromosomal Proteins, Non-Histone Cyanogen Bromide Histones Humans Leukemia L1210/analysis Mice Peptide Fragments/analysis Protein Binding Ubiquitins

Chemicals

Chromosomal Proteins, Non-Histone Histones Peptide Fragments Ubiquitins Cyanogen Bromide

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

West M H

Bonner W M

References (5)

5 references, click to expand

A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.
Eur J Biochem. 1974 Jul 1;46(1):83-8 PMID: 4850204
Non-allelic variants of histones 2a, 2b and 3 in mammals.
Nature. 1977 Mar 17;266(5599):273-5 PMID: 846573
Resolution of histones by polyacrylamide gel electrophoresis in presence of nonionic detergents.
Methods Cell Biol. 1978;17:223-33 PMID: 703614
Histone 2A, a heteromorphous family of eight protein species.
Biochemistry. 1980 Jul 8;19(14):3238-45 PMID: 7407044
Two-dimensional gel analysis of histones in acid extracts of nuclei, cells, and tissues.
Eur J Biochem. 1980 Aug;109(1):17-23 PMID: 7408874

Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/8.20.4671

Published

1980-10-24

Pages

4671-80

Language

English

Region

England

NLM ID

0411011

PMCID

PMC324378

Subset

External Links

PubMed source DOI: 10.1093/nar/8.20.4671 PMC Full Text View journal details

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