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PMID: 6255482 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Facilitation of membrane electrical excitability in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 10 ·1980-10-00 ·Pages 6216-20

Salkoff L, Wyman R

Abstract

Prior electrical activity in the indirect flight muscles of Drosophila facilitates membrane excitability. The mechanism of facilitation involves the inactivation of an early, fast, transient outward current by prior membrane depolarizaton. In the facilitated state the calcium-dependent spike-like response has a decreased current and voltage threshold. The facilitated state persists for 1.5 sec after a membrane active response. A single nerve-driven spike is sufficient to facilitate membrane excitability.

MeSH Terms
Action Potentials Animals Calcium/physiology Drosophila melanogaster/physiology Membrane Potentials Neural Inhibition Neuromuscular Junction/physiology Synaptic Transmission Time Factors
Chemicals
Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Salkoff L
Wyman R
References (12)
12 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.10.6216
Published
1980-10-00
Pages
6216-20
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC350246
Subset
IM
Grants
NINDS NIH HHS · NS07314 · United States
NINDS NIH HHS · NS14887 · United States
External Links
PubMed source DOI: 10.1073/pnas.77.10.6216 PMC Full Text View journal details
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