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PMID: 6257832 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Varicella-zoster virus transformation of hamster embryo cells.

The Journal of general virology ·Vol. 51 ·No. Pt 1 ·1980-11-00 ·Pages 171-7

Gelb LD, Huang JJ, Wellinghoff WJ

Abstract

Varicella-zoster virus infection of primary hamster embryo cells resulted in oncogenic transformation. These transformed cells exhibited virus-specific antigens by immunofluorescence and developed surface Fc receptors. They induced aggressive fibrosarcomas when injected into inbred hamsters. The tumour-bearing hamsters develop antibodies to varicella-zoster antigens.

MeSH Terms

Animals Antibodies, Viral/biosynthesis Antigens, Viral/analysis Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Cricetinae Fibrosarcoma/etiology Herpesvirus 3, Human/immunology,physiology Mesocricetus Neoplasm Transplantation Receptors, Fc Transplantation, Homologous

Chemicals

Antibodies, Viral Antigens, Viral Receptors, Fc

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Gelb L D

Huang J J

Wellinghoff W J

Article Info

Journal

The Journal of general virology

Abbr.

J Gen Virol

ISSN

0022-1317

DOI

10.1099/0022-1317-51-1-171

Published

1980-11-00

Pages

171-7

Language

English

Region

England

NLM ID

0077340

Subset

Grants

NIAID NIH HHS · AI00495 · United States

NIAID NIH HHS · AI13219 · United States

NCI NIH HHS · CA9129 · United States

External Links

PubMed source DOI: 10.1099/0022-1317-51-1-171 View journal details

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Varicella-zoster virus transformation of hamster embryo cells.

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