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PMID: 6259129 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cyclic adenosine 3',5'-monophosphate levels in Pseudomonas putida and Pseudomonas aeruginosa during induction and carbon catabolite repression of histidase synthesis.

Journal of bacteriology ·Vol. 145 ·No. 3 ·1981-03-00 ·Pages 1286-92

Phillips AT, Mulfinger LM

Abstract

Inducibility of histidase (histidine ammonia-lyase, EC 4.3.1.3) in Pseudomonas putida and Pseudomonas aeruginosa was observed to be strongly affected by succinate-provoked catabolite repression, but this did not occur as a consequence of reduced intracellular cyclic adenosine 3',5'-monophosphate levels, and repression could not be alleviated by exogenously added cyclic adenosine 3,'5'-monophosphate. Milder repression of histidase by lactate was also not reversed by the addition of cyclic adenosine 3',5'-monophosphate. These results, along with data showing intracellular cyclic adenosine 3',5'-monophosphate levels remained essentially constant during growth on such diverse carbon sources as histidine, acetamide, glucose, and succinate, indicated that catabolite repression of histidase synthesis by efficient carbon sources was not mediated through variations in internal cyclic adenosine 3,'5'-monophosphate.

MeSH Terms

Ammonia-Lyases/biosynthesis Cyclic AMP/metabolism Enzyme Induction Enzyme Repression Histidine Ammonia-Lyase/biosynthesis Lactates/pharmacology Pseudomonas/enzymology Pseudomonas aeruginosa/enzymology Succinates/pharmacology

Chemicals

Lactates Succinates Cyclic AMP Ammonia-Lyases Histidine Ammonia-Lyase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Phillips A T

Mulfinger L M

References (23)

23 references, click to expand

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.145.3.1286-1292.1981

Published

1981-03-00

Pages

1286-92

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC217130

Subset

Grants

NIADDK NIH HHS · AM 13,198 · United States

External Links

PubMed source DOI: 10.1128/jb.145.3.1286-1292.1981 PMC Full Text View journal details

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Cyclic adenosine 3',5'-monophosphate levels in Pseudomonas putida and Pseudomonas aeruginosa during induction and carbon catabolite repression of histidase synthesis.

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