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PMID: 6259539 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The SV40 early region TATA box is required for accurate in vitro initiation of transcription.

Nature ·Vol. 290 ·No. 5804 ·1981-03-26 ·Pages 310-5

Mathis DJ, Chambon P

Abstract

The SV40 early region TATA box functions in vitro to fix initiation of transcription within a narrow region identical to that in vivo. In the absence of the TATA box region initiation occurs at multiple specific sites, as in vivo. However, certain sequences far upstream, crucial for efficient in vivo expression, are not essential in vitro.

MeSH Terms

Base Sequence Binding Sites Cell-Free System DNA, Viral/genetics Operon RNA Polymerase II/metabolism Simian virus 40/genetics Transcription, Genetic

Chemicals

DNA, Viral RNA Polymerase II

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mathis D J

Chambon P

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/290310a0

Published

1981-03-26

Pages

310-5

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

J02400, J02402, J02403, J02406, J02407, J02408, J02409, J02410, V01380

External Links

PubMed source DOI: 10.1038/290310a0 View journal details

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The SV40 early region TATA box is required for accurate in vitro initiation of transcription.

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