Abstract
Mutations at the gyrB locus were found to decrease the degree of supercoiling of the Escherichia coli chromosome. The effect of a gyrB mutation on the repair of ultraviolet-induced deoxyribonucleic acid damage was studied by following the killing of strains of E. coli K-12 proficient and deficient in deoxyribonucleic acid repair. The effectiveness of both excision and postreplication types of deoxyribonucleic acid repair was found to be altered by this mutation, the former being apparently enhanced and the latter impaired.
MeSH Terms
Chromosomes, Bacterial/analysis
DNA Repair
DNA Topoisomerases, Type II/genetics
DNA, Bacterial/genetics
DNA, Superhelical/genetics
Escherichia coli/genetics,radiation effects
Mutation
Ultraviolet Rays
Chemicals
DNA, Bacterial
DNA, Superhelical
DNA Topoisomerases, Type II
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
von Wright A
Bridges B A
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16 references, click to expand
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