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PMID: 6264273 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of DNA gyrase inhibitors on gene expression of the cysteine regulon.

Molecular & general genetics : MGG ·Vol. 181 ·No. 3 ·1981-00-00 ·Pages 363-6

Ostrowski J, Hulanicka D

Abstract

Nalidixic acid inhibits the expression of those cysteine genes which are regulated by the cysB product, it has no affect, however, on the constitutively-expressed cysE gene. The expression of cysteine genes in a strain carrying a mutation in the nalA locus is resistant to this drug. Novobiocin affects the expression of cysteine genes similarly to nalidixic acid. The effect of nalidixic acid on the expression of genes in a cysteine constitutive mutant was studied.

MeSH Terms
Acetyltransferases/genetics Cysteine/genetics Cysteine Synthase/genetics Gene Expression Regulation/drug effects Genes, Regulator Mutation Nalidixic Acid/pharmacology Novobiocin/pharmacology Oxidoreductases Acting on Sulfur Group Donors/genetics Salmonella typhimurium/genetics Serine O-Acetyltransferase Topoisomerase II Inhibitors
Chemicals
Topoisomerase II Inhibitors Novobiocin Nalidixic Acid Oxidoreductases Acting on Sulfur Group Donors Acetyltransferases Serine O-Acetyltransferase Cysteine Synthase Cysteine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ostrowski J
Hulanicka D
References (19)
19 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00425612
Published
1981-00-00
Pages
363-6
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00425612
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