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PMID: 6267421 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Regulation of the synthesis of adenylate cyclase in Escherichia coli by the cAMP -- cAMP receptor protein complex.

Molecular & general genetics : MGG ·Vol. 181 ·No. 4 ·1981-00-00 ·Pages 470-5

Majerfeld IH, Miller D, Spitz E, Rickenberg HV

Abstract

The synthesis of the adenylate cyclase [ATP pyrophosphatelyase-(cyclizing), E.C. 4.6.1.1.] of Escherichia coli, appears to be regulated negatively by the cAMP receptor protein, CRP. This conclusion is based on a comparison of adenylate cyclase activities measured in vitro with the rates of cAMP synthesis by intact bacteria. The activity of adenylate cyclase, depending on conditions of growth, is also regulated by CRP; this effect, however, is indirect insofar as it is mediated by a protein or proteins under CRP control.

MeSH Terms
Adenylyl Cyclases/genetics,metabolism Cyclic AMP/physiology Escherichia coli/enzymology,genetics Gene Expression Regulation/drug effects Glucose/pharmacology Glucosephosphates/pharmacology Mutation Receptors, Cyclic AMP/genetics,physiology
Chemicals
Glucosephosphates Receptors, Cyclic AMP Cyclic AMP Adenylyl Cyclases Glucose
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Majerfeld I H
Miller D
Spitz E
Rickenberg H V
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30 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00428738
Published
1981-00-00
Pages
470-5
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
Grants
NIADDK NIH HHS · AM 11046 · United States
External Links
PubMed source DOI: 10.1007/BF00428738
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