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PMID: 6268213 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Interpreting power spectra from nonstationary membrane current fluctuations.

Biophysical journal ·Vol. 35 ·No. 2 ·1981-08-00 ·Pages 289-300

Sigworth FJ

Abstract

It is often desirable to characterize membrane current fluctuations from ionic channels under conditions in which the mean current and the variance of the fluctuations change with time. A simple theory is developed that relates the power spectrum to the channel characteristics under such nonstationary conditions, assuming that the mean current time-course has been removed from the fluctuation records. Strategies for removing the mean time-course are discussed, the spectra are calculated from simulated channel fluctuations for comparison with the theory.

MeSH Terms
Computers Ion Channels/physiology Kinetics Mathematics Membrane Potentials Membranes/physiology Models, Biological
Chemicals
Ion Channels
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sigworth F J
References (8)
8 references, click to expand
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(81)84790-X
Published
1981-08-00
Pages
289-300
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1327523
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(81)84790-X PMC Full Text View journal details
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