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PMID: 6269238 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Cyclosporin A and steroid therapy in sixty-six cadaver kidney recipients.

Surgery, gynecology & obstetrics ·Vol. 153 ·No. 4 ·1981-10-00 ·Pages 486-94

Starzl TE, Klintmalm GB, Weil R, Porter KA, Iwatsuki S, Schroter GP, Fernandez-Bueno C, MacHugh N

Abstract

From nine to 18 months ago, 66 patients were given 67 randomly matched cadaveric kidneys with cyclosporin A and steroid therapy. Nine of the recipients were undergoing retransplantation. The over-all kidney survival rate to date has been 77.6 per cent, and 78.8 per cent of the recipients are dialysis-free. The patient mortality in this learning phase was 13.3 per cent. Nephrotoxicity, hepatotoxicity and other side-effects of cyclosporin A could usually be dealt with by dosage adjustments, making feasible the chronic use of this agent. One B-cell immunoblastic sarcoma was encountered which was monoclonal. It was not responsible for death. Another patient had a perforation of the intestine from a lympho-proliferative reaction in which the B cells were polyclonal. After jejunal resection a year ago, there were no further complications. This lesion was not classified as a lymphoma. Both lympho-proliferative lesions were associated with a rise in antibody to viral capsid antigen of Epstein-Barr virus. Results of this study have verified the effectiveness and relative safety of cyclosporin A with steroids for immunosuppression in human recipients of cadaveric kidneys.

MeSH Terms
Adolescent Adult Antibodies, Viral/analysis Cadaver Cyclosporins/adverse effects,therapeutic use Female Follow-Up Studies Graft Rejection/drug effects Graft Survival Hepatitis B Surface Antigens/analysis Herpesvirus 4, Human/immunology Humans Immunosuppression Therapy Kidney Transplantation Male Middle Aged Prednisone/therapeutic use
Chemicals
Antibodies, Viral Cyclosporins Hepatitis B Surface Antigens Prednisone
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Starzl T E
Klintmalm G B
Weil R
Porter K A
Iwatsuki S
Schroter G P
Fernandez-Bueno C
MacHugh N
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Article Info
Journal
Surgery, gynecology & obstetrics
Abbr.
Surg Gynecol Obstet
ISSN
0039-6087
Published
1981-10-00
Pages
486-94
Language
English
Region
United States
NLM ID
0101370
PMCID
PMC2671391
Subset
IM
Grants
NCRR NIH HHS · RR-00051 · United States
NIADDK NIH HHS · R01 AM007772 · United States
NIADDK NIH HHS · AM-17260 · United States
NCRR NIH HHS · M01 RR000069 · United States
NIADDK NIH HHS · AM-07772 · United States
NCRR NIH HHS · M01 RR000051 · United States
NIDDK NIH HHS · R01 AM007772 · United States
External Links
PubMed source PMC Full Text View journal details
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