Growth and persistence of polyoma early region deletion mutants in mice.

Journal of virology ·Vol. 39 ·No. 3 ·1981-09-00 ·Pages 958-62

McCance DJ

Abstract

Replication of early region deletion mutations in polyoma in the kidneys of mice was in most cases reduced by 10- to 10,000-fold, as compared with wild-type polyoma, and the mutants failed to produce the persistent infection observed with wild-type polyoma.

MeSH Terms

Animals Antigens, Neoplasm/genetics Antigens, Viral/genetics Antigens, Viral, Tumor Genes, Viral Kidney/microbiology Mice Mutation Polyomavirus/genetics,growth & development Tumor Virus Infections/microbiology Virus Replication

Chemicals

Antigens, Neoplasm Antigens, Viral Antigens, Viral, Tumor

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

McCance D J

References (14)

14 references, click to expand

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Analysis of host range of nontransforming polyoma virus mutants.
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Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
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Transplacental transmission of polyoma virus in mice.
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Reactivation of polyoma virus in kidneys of persistently infected mice during pregnancy.
Infect Immun. 1979 Sep;25(3):998-1002 PMID: 227790
Construction and analysis of viable deletion mutants of polyoma virus.
J Virol. 1979 Nov;32(2):523-9 PMID: 228075
BK virus DNA: complete nucleotide sequence of a human tumor virus.
Science. 1979 Oct 26;206(4417):456-62 PMID: 228391
New classes of viable deletion mutants in the early region of polyoma virus.
J Virol. 1979 Sep;31(3):645-56 PMID: 229246
Coding potential and regulatory signals of the polyoma virus genome.
Nature. 1980 Jan 31;283(5746):445-53 PMID: 6243401
Regulatory mutants of polyoma virus defective in DNA replication and the synthesis of early proteins.
Cell. 1980 Jun;20(2):401-9 PMID: 6248242
Comparison of polyoma virus transcription in productively infected mouse cells and transformed rodent cell lines.
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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.39.3.958-962.1981

Published

1981-09-00

Pages

958-62

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC171331

Subset

External Links

PubMed source DOI: 10.1128/JVI.39.3.958-962.1981 PMC Full Text View journal details

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Growth and persistence of polyoma early region deletion mutants in mice.

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