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PMID: 6271922 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The persistence of papovavirus BK DNA sequences in normal human renal tissue.

Journal of medical virology ·Vol. 8 ·No. 2 ·1981-00-00 ·Pages 143-50

Heritage J, Chesters PM, McCance DJ

Abstract

Evidence has accumulated indicating that BK virus, following an inapparent primary infection, persists in the renal organs of normal healthy individuals and reactivates upon immunosuppression. Data to support this hypothesis are presented and suggest that BK virus DNA sequences are present at very low levels in the kidneys of more than 50% of the population and that this persistence is localized in several foci within these organs.

MeSH Terms

Aged BK Virus/analysis Base Sequence DNA Restriction Enzymes DNA, Viral/analysis Female Humans Infant, Newborn Kidney/analysis Kidney Cortex/analysis Kidney Medulla/analysis Male Middle Aged Nucleic Acid Hybridization Polyomavirus/analysis

Chemicals

DNA, Viral DNA Restriction Enzymes

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Heritage J

Chesters P M

McCance D J

Article Info

Journal

Journal of medical virology

Abbr.

J Med Virol

ISSN

0146-6615

DOI

10.1002/jmv.1890080208

Published

1981-00-00

Pages

143-50

Language

English

Region

United States

NLM ID

7705876

Subset

External Links

PubMed source DOI: 10.1002/jmv.1890080208 View journal details

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The persistence of papovavirus BK DNA sequences in normal human renal tissue.

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