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PMID: 6272316 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Human nucleolus organizers on nonhomologous chromosomes can share the same ribosomal gene variants.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 9 ·1981-09-00 ·Pages 5744-8

Krystal M, D'Eustachio P, Ruddle FH, Arnheim N

Abstract

The distributions of three human ribosomal gene polymorphisms among individual chromosomes containing nucleolus organizers were analyzed by using mouse--human hybrid cells. Different nucleolus organizers can contain the same variant, suggesting the occurrence of genetic exchanges among ribosomal gene clusters on nonhomologous chromosomes. Such exchanges appear to occur less frequently in mice. This difference is discussed in terms of the nucleolar organization and chromosomal location of ribosomal gene clusters in humans and mice.

MeSH Terms
Animals Cell Nucleolus/physiology DNA Restriction Enzymes Gene Frequency Genes Humans Hybrid Cells Mice Nucleolus Organizer Region/physiology Polymorphism, Genetic RNA, Ribosomal/genetics Repetitive Sequences, Nucleic Acid
Chemicals
RNA, Ribosomal DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Krystal M
D'Eustachio P
Ruddle F H
Arnheim N
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26 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.9.5744
Published
1981-09-00
Pages
5744-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC348849
Subset
IM
Grants
NIGMS NIH HHS · GM 09966 · United States
NIGMS NIH HHS · GM 2536501 · United States
External Links
PubMed source DOI: 10.1073/pnas.78.9.5744 PMC Full Text View journal details
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