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PMID: 6275839 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Increased phosphorylation of ribosomal protein S6 in hamster fibroblasts transformed by polyoma virus and simian virus 40.

The Biochemical journal ·Vol. 198 ·No. 1 ·1981-07-15 ·Pages 235-7

Kennedy IM, Leader DP

Abstract

The extent of phosphorylation of ribosomal protein S6 was compared in normal hamster fibroblasts and in fibroblasts transformed by polyoma virus or simian virus 40. In both strains of transformed cells the protein was more highly phosphorylated than in the normal cells.

MeSH Terms

Animals Cell Line Cell Transformation, Viral Cricetinae Fibroblasts/metabolism Kidney Phosphorylation Polyomavirus Ribosomal Protein S6 Ribosomal Proteins/metabolism Simian virus 40

Chemicals

Ribosomal Protein S6 Ribosomal Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kennedy I M

Leader D P

References (14)

14 references, click to expand

Ribosomal proteins. VII. Two-dimensional polyacrylamide gel electrophoresis for fingerprinting of ribosomal proteins.
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The transformation of BHK 21 hamster cells by simian virus 40.
Int J Cancer. 1972 Sep 15;10(2):296-309 PMID: 4350188
Role of cyclic nucleotides in cancer.
Adv Cyclic Nucleotide Res. 1974;4(0):81-116 PMID: 4369152
The phosphorylation of liver ribosomal proteins in vivo. Evidence that only a single small subunit protein (S6) is phosphorylated.
J Biol Chem. 1974 Nov 10;249(21):6917-25 PMID: 4423396
Influence of glucagon and cyclic adenosine 3':5'-monophosphate on the phosphorylation of rat liver ribosomal protein S6.
J Biol Chem. 1976 Mar 10;251(5):1500-4 PMID: 176154
The phosphorylation of ribosomal protein S6 in baby hamster kidney fibroblasts.
Biochem Biophys Res Commun. 1976 Aug 23;71(4):966-74 PMID: 971322
An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates.
Cell. 1979 Dec;18(4):925-33 PMID: 229973
Simian virus 40 gene A regulates the association between a highly phosphorylated protein and chromatin and ribosomes in simian virus 40-transformed cells.
J Virol. 1977 Jun;22(3):679-93 PMID: 195084
Phosphorylation of ribosomal protein S6 in suspension cultured HeLa cells.
Mol Gen Genet. 1977 Apr 29;152(3):223-30 PMID: 876026
The phosphorylation of ribosomal protein S6 on the monoribosomes and polyribosomes of baby hamster kidney fibroblasts.
FEBS Lett. 1978 Jun 15;90(2):270-4 PMID: 668891
Phosphorylation of chromatin- and ribosome-associated proteins in cells transformed by adenovirus, murine sarcoma virus, and methylcholanthrene.
J Virol. 1978 Sep;27(3):800-8 PMID: 212594
Enzymatic activities associated with a purified simian virus 40 T antigen-related protein.
Proc Natl Acad Sci U S A. 1979 Feb;76(2):610-4 PMID: 218212
Insulin-like growth factor: insulin or serum increase phosphorylation of ribosomal protein S6 during transition of stationary chick embryo fibroblasts into early G1 phase of the cell cycle.
FEBS Lett. 1979 Apr 1;100(1):185-90 PMID: 571354
The phosphorylation of the ribosomal proteins of Krebs II ascites cells.
Biochim Biophys Acta. 1977 Jan 20;474(2):293-307 PMID: 831819

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1980235

Published

1981-07-15

Pages

235-7

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1163234

Subset

External Links

PubMed source DOI: 10.1042/bj1980235 PMC Full Text View journal details

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Increased phosphorylation of ribosomal protein S6 in hamster fibroblasts transformed by polyoma virus and simian virus 40.

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