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PMID: 6278073 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Restriction endonuclease analysis of varicella-zoster vaccine virus and wild-type DNAs.

Journal of medical virology ·Vol. 9 ·No. 1 ·1982-00-00 ·Pages 69-76

Martin JH, Dohner DE, Wellinghoff WJ, Gelb LD

Abstract

The DNA from several clinical isolates of varicella-zoster virus (VZV) were compared with the DNA from the vaccine strain VZV using three restriction endonucleases: BamHI, BgII, and HpaI. When electrophoresed through an agarose gel, the vaccine DNA digestion pattern was significantly different from the digestion patterns of the wild-type DNAs. Variations in the digestion pattern of the separate clinical isolates were also observed.

MeSH Terms

Bacterial Proteins Capsid/isolation & purification DNA Restriction Enzymes/pharmacology DNA, Viral/analysis Deoxyribonuclease BamHI Deoxyribonucleases, Type II Site-Specific Electrophoresis, Agar Gel Embryo, Mammalian Fibroblasts Herpesvirus 3, Human/genetics,immunology Humans Viral Vaccines/analysis

Chemicals

Bacterial Proteins DNA, Viral Viral Vaccines DNA Restriction Enzymes Deoxyribonuclease BamHI endodeoxyribonuclease HpaI BglII endonuclease Deoxyribonucleases, Type II Site-Specific

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Martin J H

Dohner D E

Wellinghoff W J

Gelb L D

Article Info

Journal

Journal of medical virology

Abbr.

J Med Virol

ISSN

0146-6615

DOI

10.1002/jmv.1890090110

Published

1982-00-00

Pages

69-76

Language

English

Region

United States

NLM ID

7705876

Subset

Grants

NCI NIH HHS · CA9129 · United States

NIAID NIH HHS · N01 AIO2639 · United States

NIAID NIH HHS · R01 AI13219 · United States

External Links

PubMed source DOI: 10.1002/jmv.1890090110 View journal details

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Restriction endonuclease analysis of varicella-zoster vaccine virus and wild-type DNAs.

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