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PMID: 6279817 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Synthesis and characterization of iodoazidobenzylpindolol.

Journal of pharmaceutical sciences ·Vol. 71 ·No. 3 ·1982-03-00 ·Pages 305-7

Rashidbaigi A, Ruoho AE

Abstract

A high affinity beta-adrenergic ligand, iodoazidobenzylpindolol, was synthesized and characterized. The absorption spectrum of this compound changed markedly upon photolysis, consistent with decomposition of the azide group. This compound has a KD of 5--7 x 10(-10) M for the duck erythrocyte ghost beta-adrenergic receptor when measured in a competitive binding assay.

MeSH Terms

Affinity Labels/chemical synthesis Animals Azides Binding, Competitive Ducks Erythrocytes/metabolism In Vitro Techniques Pindolol/analogs & derivatives,blood,chemical synthesis Receptors, Adrenergic, beta/metabolism

Chemicals

Affinity Labels Azides Receptors, Adrenergic, beta 1-(indol-4-yloxy)-3-(1-(4-azido-3-iodophenyl)-2-isobutylamine)-2-propanol Pindolol

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rashidbaigi A

Ruoho A E

Article Info

Journal

Journal of pharmaceutical sciences

Abbr.

J Pharm Sci

ISSN

0022-3549

DOI

10.1002/jps.2600710310

Published

1982-03-00

Pages

305-7

Language

English

Region

United States

NLM ID

2985195R

Subset

Grants

NINDS NIH HHS · NS-00158 · United States

NINDS NIH HHS · NS-12392 · United States

External Links

PubMed source DOI: 10.1002/jps.2600710310 View journal details

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Synthesis and characterization of iodoazidobenzylpindolol.

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