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PMID: 6280012 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Studies on the mechanism of thyroid hormone stimulation in vitro of human red cell Ca2+-ATPase activity.

Life sciences ·Vol. 30 ·No. 7-8 ·1982-00-00 ·Pages 675-82

Davis PJ, Davis FB, Blas SD

Abstract

The stimulation in vitro of human red blood cell Ca2+-ATPase activity by thyroxine (T4) and triiodothyronine (T3) in physiological concentrations is shown to depend upon binding of iodothyronines to red cell membranes. Calmodulin enhances the activity of thyroid hormone in this model system but there is no direct interaction of calmodulin and hormone.

MeSH Terms

Calcium-Transporting ATPases/blood Calmodulin/physiology Enzyme Activation Erythrocyte Membrane/metabolism Erythrocytes/drug effects,enzymology Humans Iodides/blood Kinetics Receptors, Cell Surface/metabolism Receptors, Thyroid Hormone Thyroxine/blood,pharmacology Triiodothyronine/pharmacology

Chemicals

Calmodulin Iodides Receptors, Cell Surface Receptors, Thyroid Hormone Triiodothyronine Calcium-Transporting ATPases Thyroxine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Davis P J

Davis F B

Blas S D

Article Info

Journal

Life sciences

Abbr.

Life Sci

ISSN

0024-3205

DOI

10.1016/0024-3205(82)90283-1

Published

1982-00-00

Pages

675-82

Language

English

Region

Netherlands

NLM ID

0375521

Subset

Grants

NIADDK NIH HHS · AM 26113 · United States

External Links

PubMed source DOI: 10.1016/0024-3205(82)90283-1 View journal details

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Studies on the mechanism of thyroid hormone stimulation in vitro of human red cell Ca2+-ATPase activity.

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