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PMID: 6282200 Published · ppublish English Comparative Study Journal Article

Susceptibility of gram-positive cocci to various antibiotics, including cefotaxime, moxalactam, and N-formimidoyl thienamycin.

Antimicrobial agents and chemotherapy ·Vol. 20 ·No. 4 ·1981-10-00 ·Pages 553-5

Cherubin CE, Corrado ML, Sierra MF, Gombert ME, Shulman M

Abstract

The activities of cefotaxime, moxalactam, MK 0787 (N-formimidoyl thienamycin), ampicillin, oxacillin, vancomycin, and clindamycin were compared against gram-positive cocci. MK 0787 was the most active and moxalactam was the least active of these drugs, except against methicillin-resistant Staphylococcus aureus, where vancomycin was most active, and penicillin-resistant pneumococci, where cefotaxime was more active.

MeSH Terms
Ampicillin/pharmacology Anti-Bacterial Agents/pharmacology Cefotaxime/pharmacology Cephalosporins/pharmacology Cephamycins/pharmacology Imipenem Lactams/pharmacology Microbial Sensitivity Tests Moxalactam Oxacillin/pharmacology Staphylococcus/drug effects Staphylococcus aureus/drug effects Streptococcus/drug effects Streptococcus pneumoniae/drug effects
Chemicals
Anti-Bacterial Agents Cephalosporins Cephamycins Lactams Imipenem Ampicillin Cefotaxime Oxacillin Moxalactam
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Cherubin C E
Corrado M L
Sierra M F
Gombert M E
Shulman M
References (7)
7 references, click to expand
  1. In vitro activity of thienamycin.
    Antimicrob Agents Chemother. 1978 Sep;14(3):436-8 PMID: 708019
  2. HR 756, a highly active cephalosporin: comparison with cefazolin and carbenicillin.
    Antimicrob Agents Chemother. 1978 Dec;14(6):807-11 PMID: 253572
  3. Antibacterial activity of a new 1-oxa cephalosporin compared with that of other beta-lactam compounds.
    Antimicrob Agents Chemother. 1979 Aug;16(2):141-9 PMID: 314774
  4. In vitro activity of LY127935.
    Antimicrob Agents Chemother. 1979 Sep;16(3):287-92 PMID: 507785
  5. Influence of inoculum size on activity of cefoperazone, cefotaxime, moxalactam, piperacillin, and N-formimidoyl thienamycin (MK0787) against Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1980 Dec;18(6):893-6 PMID: 6263178
  6. In vitro activity of Ro 13-9904, a new beta-lactamase-stable cephalosporin.
    Antimicrob Agents Chemother. 1981 Feb;19(2):222-5 PMID: 6289726
  7. Use of autoclaved extracts of hemolytic streptococci for serological grouping.
    Stanford Med Bull. 1955 May;13(2):290-1 PMID: 14386182
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
Published
1981-10-00
Pages
553-5
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC181744
Subset
IM
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