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PMID: 6287421 Published · ppublish English Journal Article

Expression of Drosophila heat shock genes is regulated in Rat-cells.

Nucleic acids research ·Vol. 10 ·No. 13 ·1982-07-10 ·Pages 3821-30

Burke JF, Ish-Horowicz D

Abstract

We have introduced a Drosophila 87A heat shock locus into the genome of Rat-1 cells. A brief heat shock of a resultant transformed line, Rhs11, induces the transcription of the Drosophila heat shock genes from the Drosophila heat shock promoter. This suggests that the induction mechanism and regulatory sequences for the heat shock response have been conserved between Drosophila and mammals.

MeSH Terms
Animals Cell Line DNA Restriction Enzymes DNA, Recombinant Drosophila/genetics Genes Heat-Shock Proteins Hot Temperature Plasmids Proteins/genetics Rats Transcription, Genetic Transformation, Genetic
Chemicals
DNA, Recombinant Heat-Shock Proteins Proteins DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Burke J F
Ish-Horowicz D
References (21)
21 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/10.13.3821
Published
1982-07-10
Pages
3821-30
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320761
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/10.13.3821 PMC Full Text View journal details
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