Home LiteratureArticle Details

PMID: 6289062 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

In vitro stimulation of lymphocytes by different strains of cytomegalovirus.

Medical microbiology and immunology ·Vol. 171 ·No. 1 ·1982-00-00 ·Pages 53-7

Gärtner L, Wilhelm JA, Czieschnek R

Abstract

The in vitro stimulation of lymphocytes from 15 healty adult donors by 5 different stains of CMV resulted in a positive stimulation ratio of lymphocytes from CMV seropositive donors with each of the 5 different strains. Differences in the absolute strength of the response was observed among the 5 strains for each individual, but we concluded that the use of antigen prepared with 1 strain of CMV is sufficient to obtain a positive or negative result. A maximum value for the in vitro lymphocyte stimulation test, however, will only be obtained using different antigen concentrations from several different CMV strains simultaneously.

MeSH Terms

Antigens, Viral/immunology Cytomegalovirus/classification,immunology Humans Immunity, Cellular Lymphocyte Activation

Chemicals

Antigens, Viral

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Gärtner L

Wilhelm J A

Czieschnek R

References (14)

14 references, click to expand

Stimulation of human lymphocytes by cytomegalovirions and dense bodies.
Med Microbiol Immunol. 1978 Nov 17;166(1-4):81-9 PMID: 214689
Lymphocyte blastogenesis and interferon production in adult human leukocyte cultures stimulated with cytomegalovirus antigens.
Infect Immun. 1980 Oct;30(1):17-22 PMID: 6160103
Comparison of in vitro lymphocyte proliferations induced by cytomegalovirus-infected human fibroblasts and cell-free cytomegalovirus.
Infect Immun. 1980 Dec;30(3):621-7 PMID: 6262238
In vitro stimulation of human lymphocytes by purified cytomegalovirus.
Intervirology. 1975-1976;6(4-5):249-57 PMID: 186434
Cell-mediated immunity in cytomegalovirus infections--a review.
Comp Immunol Microbiol Infect Dis. 1980;3(3):283-90 PMID: 6258855
Lymphocyte transformation and interferon production in human mononuclear cell microcultures for assay of cellular immunity to herpes simplex virus.
Infect Immun. 1976 Jul;14(1):47-54 PMID: 181328
Cytomegalovirus-directed lymphocyte reactivity in healthy adults tested by a CMV-induced lymphocyte transformation test.
Clin Exp Immunol. 1977 Jul;29(1):52-60 PMID: 70294
Cell-mediated immunity of cytomegalovirus infection in normal subjects and cardiac transplant patients.
J Infect Dis. 1978 May;137(5):541-9 PMID: 207783
Strain-specific local and systemic cell-mediated immune responses to cytomegalovirus in humans.
Infect Immun. 1978 Apr;20(1):82-7 PMID: 78898
Cell-mediated immunity to cytomegalovirus in immunocompromised patients: effect of radiation or chemotherapy.
Infect Immun. 1979 Oct;26(1):217-24 PMID: 227793
Application of different strains for determining IgM antibodies against cytomegalovirus-induced late antigen.
Arch Virol. 1982;72(1-2):133-5 PMID: 6285863
A study of complement-fixing, immunofluorescent, and neutralizing antibodies in human cytomegalovirus infections.
Z Immunitatsforsch Exp Klin Immunol. 1971 Jun;141(5):411-29 PMID: 4326069
Acute cytomegalovirus infection and the host immune response. I. Development and maintenance of cytomegalovirus (CMV) induced in vitro lymphocyte reactivity and its relationship to the production of CMV antibodies.
Clin Exp Immunol. 1980 Feb;39(2):263-71 PMID: 6248279
Specific cell-mediated immunity in children with congenital and neonatal cytomegalovirus infection and their mothers.
J Infect Dis. 1979 Oct;140(4):493-9 PMID: 229171

Article Info

Journal

Medical microbiology and immunology

Abbr.

Med Microbiol Immunol

ISSN

0300-8584

DOI

10.1007/BF02122707

Published

1982-00-00

Pages

53-7

Language

English

Region

Germany

NLM ID

0314524

Subset

External Links

PubMed source DOI: 10.1007/BF02122707 View journal details

Analysis Services

In vitro stimulation of lymphocytes by different strains of cytomegalovirus.

Contact

WeChat Official Account