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PMID: 6289728 Published · ppublish English Journal Article

Macrolide-lincosamide-streptogramin resistance patterns in Clostridium perfringens from animals.

Antimicrobial agents and chemotherapy ·Vol. 19 ·No. 2 ·1981-02-00 ·Pages 274-8

Dutta GN, Devriese LA

Abstract

Different patterns of resistance against commonly used macrolide, lincosamide, and streptogramin antibiotics were found in Clostridium perfringens of animal origin. The patterns were designated as (i) macrolide-lincosamide-streptogramin group B generalized resistance, (ii) macrolide-lincosamide generalized resistance, (iii) macrolide-lincosamide inducible resistance, and (iv) macrolide-lincosamide-streptogramin low-level generalized resistance. The strains of the fourth pattern were able to inactivate pristinamycin and virginiamycin. The macrolide-susceptible strains showed a bimodal distribution of lincomycin and clindamycin susceptibility levels. The susceptible strains were inhibited by 0.25 micrograms of lincomycin per ml and 0.03 micrograms of clindamycin per ml. The low-level resistant strains were inhibited at concentrations of 2 to 4 micrograms of lincomycin per ml and 0.5 to 2 micrograms of clindamycin per ml.

MeSH Terms
Animals Anti-Bacterial Agents/pharmacology Cattle Clindamycin/pharmacology Clostridium perfringens/drug effects Culture Media Drug Resistance, Microbial Lincomycin/pharmacology Microbial Sensitivity Tests Swine Virginiamycin/pharmacology
Chemicals
Anti-Bacterial Agents Culture Media Virginiamycin Clindamycin Lincomycin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dutta G N
Devriese L A
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21 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.19.2.274
Published
1981-02-00
Pages
274-8
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC181408
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.19.2.274 PMC Full Text View journal details
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