Persistent infection of humans with hepatitis B virus: mechanisms and consequences.

Reviews of infectious diseases ·Vol. 4 ·No. 5 ·1982-00-00 ·Pages 1026-47

Ganem D

Abstract

Although most infections of humans with hepatitis B virus are self-limited, up to 10% of individuals experiencing primary infection remain persistently infected. These individuals are usually asymptomatic but may suffer episodic or progressive liver injury that can result in cirrhosis and liver failure. In addition, chronic infection with hepatitis B virus is, in certain settings, associated with the late development of primary hepatocellular carcinoma. This review summarizes the biological characteristics of persistent viral infection, with particular emphasis on host and viral factors that affect the outcome of primary infection.

MeSH Terms

Adolescent Adult Aging Animals Carcinoma, Hepatocellular/etiology Carrier State Child Child, Preschool Chronic Disease DNA, Viral/analysis Disease Models, Animal Genes, Viral Hepatitis B/physiopathology Hepatitis B Antibodies/analysis Hepatitis B Core Antigens/immunology Hepatitis B Surface Antigens/analysis Hepatitis B e Antigens/analysis Hepatitis B virus/physiology Humans Immune Tolerance Infant Infant, Newborn Liver/analysis,microbiology Liver Cirrhosis/etiology Liver Neoplasms Marmota/microbiology Middle Aged Sex Factors Time Factors Virus Replication

Chemicals

DNA, Viral Hepatitis B Antibodies Hepatitis B Core Antigens Hepatitis B Surface Antigens Hepatitis B e Antigens

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ganem D

Article Info

Journal

Reviews of infectious diseases

Abbr.

Rev Infect Dis

ISSN

0162-0886

DOI

10.1093/clinids/4.5.1026

Published

1982-00-00

Pages

1026-47

Language

English

Region

United States

NLM ID

7905878

Subset

External Links

PubMed source DOI: 10.1093/clinids/4.5.1026

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Persistent infection of humans with hepatitis B virus: mechanisms and consequences.

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