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PMID: 6294604 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

A tandem repeat gene in a picornavirus.

Nucleic acids research ·Vol. 10 ·No. 20 ·1982-10-25 ·Pages 6441-50

Forss S, Schaller H

Abstract

Three closely related genes for the small genome-linked protein (VPg) of picornaviruses have been identified by sequence analysis as a tandem repeat in the genome of Foot and Mouth Disease Virus (FMDV), strain O1K. This unusual structure was also found in the genome of strain C1O, belonging to a different FMDV serotype. Predicted biochemical properties of the three VPg gene products are in excellent agreement with the data from protein analysis of a heterogeneous VPg population from a third FMDV serotype, strain A10 (1). Taken together, these data indicate that the VPgs from all three genes function equally well in vivo. This is the first report of a tandem repeat gene in a viral genome.

MeSH Terms
Amino Acid Sequence Aphthovirus/genetics DNA DNA Restriction Enzymes Genes, Viral Plasmids Protein Biosynthesis Repetitive Sequences, Nucleic Acid Species Specificity Transcription, Genetic
Chemicals
DNA DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Forss S
Schaller H
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23 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/10.20.6441
Published
1982-10-25
Pages
6441-50
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326934
Subset
IM
Databases
GENBANK
J02190, J02191
External Links
PubMed source DOI: 10.1093/nar/10.20.6441 PMC Full Text View journal details
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