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PMID: 6296425 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T.

Journal of virology ·Vol. 45 ·No. 1 ·1983-01-00 ·Pages 104-13

Chen IS, Wilhelmsen KC, Temin HM

Abstract

The cellular homolog of the onc sequences in the avian retrovirus reticuloendotheliosis virus strain T (v-rel) was studied by molecular cloning and nucleic acid hybridization. In contrast to v-rel sequences, which are 1.4 kilobase pairs long, the cellular homolog, c-rel, from line 15B chickens is at least 25 kilobase pairs long, with multiple apparent introns. A 4.0-kilobase polyadenylic acid-containing RNA transcript is the primary species of c-rel RNA present in uninfected chicken cells. Sequences at the 3' end of this c-rel RNA are not present in v-rel.

MeSH Terms
Animals Base Sequence Chickens/genetics Cloning, Molecular Genes, Viral Nucleic Acid Hybridization Oncogenes RNA, Viral/genetics Reticuloendotheliosis virus/genetics Retroviridae/genetics Transcription, Genetic
Chemicals
RNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chen I S
Wilhelmsen K C
Temin H M
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29 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.45.1.104-113.1983
Published
1983-01-00
Pages
104-13
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256391
Subset
IM
Grants
NCI NIH HHS · CA-07175 · United States
NCI NIH HHS · CA-09135 · United States
NCI NIH HHS · CA-22443 · United States
External Links
PubMed source DOI: 10.1128/JVI.45.1.104-113.1983 PMC Full Text View journal details
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