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PMID: 6296794 Published · ppublish English Comparative Study Journal Article

Independently evolving chicken histone H2B genes: identification of a ubiquitous H2B-specific 5' element.

Nucleic acids research ·Vol. 10 ·No. 23 ·1982-12-11 ·Pages 7851-63

Harvey RP, Robins AJ, Wells JR

Abstract

The DNA sequence of two chicken histone H2B genes has been determined. Both genes code for the same H2B subtype. Except for conserved "promoter" elements, the sequences 5' to the protein coding regions are completely divergent, indicating that the genes are distantly related and are not evolving in concert. This presents an ideal situation for sequence comparisons. We have discovered a 13 bp, H2B specific homology block, 5' CTCATTTGCATAC 3' located close to the "TATA box". This motif is conserved in all H2B gene leader regions so far sequenced. One of the H2B genes is closely linked, in a divergent arrangement, to an H2A gene, and sequence data suggests that the linked genes share promoter elements.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Chickens DNA Restriction Enzymes Genes Histones/genetics Sea Urchins Species Specificity Xenopus
Chemicals
Histones DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Harvey R P
Robins A J
Wells J R
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25 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/10.23.7851
Published
1982-12-11
Pages
7851-63
Language
English
Region
England
NLM ID
0411011
PMCID
PMC327051
Subset
IM
Databases
GENBANK
J00864, J00865
External Links
PubMed source DOI: 10.1093/nar/10.23.7851 PMC Full Text View journal details
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