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PMID: 6297010 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells.

Science (New York, N.Y.) ·Vol. 219 ·No. 4587 ·1983-02-25 ·Pages 987-8

Canning WM, Fields BN

Abstract

Ammonium chloride, a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during infection of mouse L cells. Subsequent removal of ammonium chloride results in the rapid establishment of a persistent infection.

MeSH Terms
Ammonium Chloride/pharmacology Animals Hydrogen-Ion Concentration L Cells Lysosomes/physiology Mice Reoviridae/growth & development Reoviridae Infections/etiology Virus Replication/drug effects
Chemicals
Ammonium Chloride
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Canning W M
Fields B N
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.6297010
Published
1983-02-25
Pages
987-8
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIAID NIH HHS · AI 13178 · United States
External Links
PubMed source DOI: 10.1126/science.6297010 View journal details
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