Home LiteratureArticle Details

PMID: 6297772 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection.

Cell ·Vol. 31 ·No. 3 Pt 2 ·1982-12-00 ·Pages 543-51

Thimmappaya B, Weinberger C, Schneider RJ, Shenk T

Abstract

Two adenovirus type 5 mutants were constructed to probe the function of the virus-encoded RNA polymerase III transcripts (VA RNAs). Each mutant fails to synthesize one of the two VA RNA species. The variant that does not produce the minor VAII species grows normally. The mutant that cannot synthesize the major VAI species grows more poorly than its parent. Analysis of the mutant's growth defect indicates that the adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection.

MeSH Terms

Adenoviruses, Human/genetics Animals Cell Line Cell Transformation, Neoplastic DNA Replication DNA Restriction Enzymes DNA, Recombinant/metabolism Embryo, Mammalian Female Humans Kinetics Mutation Plasmids Pregnancy Protein Biosynthesis RNA, Messenger/genetics RNA, Viral/genetics Rabbits Reticulocytes/metabolism Virus Replication

Chemicals

DNA, Recombinant RNA, Messenger RNA, Viral DNA Restriction Enzymes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Thimmappaya B

Weinberger C

Schneider R J

Shenk T

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/0092-8674(82)90310-5

Published

1982-12-00

Pages

543-51

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/0092-8674(82)90310-5 View journal details

Analysis Services

Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection.

Contact

WeChat Official Account