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PMID: 6298715 Published · ppublish English Journal Article

Comparison of the amino acid sequence of the major immunogen from three serotypes of foot and mouth disease virus.

Nucleic acids research ·Vol. 10 ·No. 24 ·1982-12-20 ·Pages 8285-95

Makoff AJ, Paynter CA, Rowlands DJ, Boothroyd JC

Abstract

Cloned cDNA molecules from three serotypes of FMDV have been sequenced around the VP1-coding region. The predicted amino acid sequences for VP1 were compared with the published sequences and variable regions identified. The amino acid sequences were also analysed for hydrophilic regions. Two of the variable regions, numbered 129-160 and 193-204 overlapped hydrophilic regions, and were therefore identified as potentially immunogenic. These regions overlap regions shown by others to be immunogenic.

MeSH Terms
Amino Acid Sequence Antigens, Viral/genetics Aphthovirus/genetics,immunology Base Sequence Cloning, Molecular DNA/metabolism Genes, Viral Serotyping
Chemicals
Antigens, Viral DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Makoff A J
Paynter C A
Rowlands D J
Boothroyd J C
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23 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/10.24.8285
Published
1982-12-20
Pages
8285-95
Language
English
Region
England
NLM ID
0411011
PMCID
PMC327085
Subset
IM
Databases
GENBANK
J02183, J02184, J02185
External Links
PubMed source DOI: 10.1093/nar/10.24.8285 PMC Full Text View journal details
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