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PMID: 6301461 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

DNA gyrase (Topoisomerase II) from Pseudomonas aeruginosa.

Biochemical and biophysical research communications ·Vol. 110 ·No. 2 ·1983-01-27 ·Pages 694-700

Miller RV, Scurlock TR

Abstract

DNA gyrase (Topoisomerase II) has been purified from Pseudomonas aeruginosa strain PAO. This enzyme is inhibited by novobiocin and nalidixic acid. DNA gyrase from P. aeruginosa is resistant to a much higher level of nalidixic acid than is Escherichia coli DNA gyrase. This increased level of resistance may explain, at least in part, the higher levels of natural resistance exhibited by P. aeruginosa toward nalidixic acid.

MeSH Terms

Bacterial Proteins/isolation & purification Chemical Phenomena Chemistry DNA Topoisomerases, Type II/isolation & purification Drug Resistance, Microbial Nalidixic Acid/pharmacology Novobiocin/pharmacology Pseudomonas aeruginosa/enzymology Topoisomerase II Inhibitors

Chemicals

Bacterial Proteins Topoisomerase II Inhibitors Novobiocin Nalidixic Acid DNA Topoisomerases, Type II

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Miller R V

Scurlock T R

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1016/0006-291x(83)91205-6

Published

1983-01-27

Pages

694-700

Language

English

Region

United States

NLM ID

0372516

Subset

Grants

NIAID NIH HHS · AI-00449 · United States

NIAID NIH HHS · AI-12759 · United States

NIGMS NIH HHS · GM-07438 · United States

External Links

PubMed source DOI: 10.1016/0006-291x(83)91205-6 View journal details

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DNA gyrase (Topoisomerase II) from Pseudomonas aeruginosa.

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