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PMID: 6304347 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Nucleotide sequence of the envelope gene of Gardner-Arnstein feline leukemia virus B reveals unique sequence homologies with a murine mink cell focus-forming virus.

Journal of virology ·Vol. 46 ·No. 3 ·1983-06-00 ·Pages 871-80

Elder JH, Mullins JI

Abstract

The nucleotide sequence of the envelope gene and the adjacent 3' long terminal repeat (LTR) of Gardner-Arnstein feline leukemia virus of subgroup B (GA-FeLV-B) has been determined. Comparison of the derived amino acid sequence of the gp70-p15E polyprotein to those of several previously reported murine retroviruses revealed striking homologies between GA-FeLV-B gp70 and the gp70 of a Moloney virus-derived mink cell focus-forming virus. These homologies were located within the substituted (presumably xenotropic) portion of the mink cell focus-forming virus envelope gene and comprised amino acid sequences not present in three ecotropic virus gp70s. In addition, areas of insertions and deletions, in general, were the same between GA-FeLV-B and Moloney mink cell focus-forming virus, although the sizes of the insertions and deletions differed. Homologies between GA-FeLV-B and mink cell focus-forming virus gp70s is functionally significant in that they both possess expanded host ranges, a property dictated by gp70. The amino acid sequence of FeLV-B contains 12 Asn-X-Ser/Thr sequences, indicating 12 possible sites of N-linked glycosylation as compared with 7 or 8 for its murine counterparts. Comparison of the 3' LTR of GA-FeLV-B to AKR and Moloney virus LTRs revealed extensive conservation in several regions including the "CCAAT" and Goldberg-Hogness (TATA) boxes thought to be involved in promotion of transcription and in the repeat region of the LTR. The inverted repeats that flanked the LTR of GA-FeLV-B were identical to the murine inverted repeats, but were one base longer than the latter. The region of U3 corresponding to the approximately 75-nucleotide "enhancer sequence" is present in GA-FeLV-B, but contains deletions relative to AKR and Moloney virus and is not repeated. An interesting pallindrome in the repeat region immediately 3' to the U3 region was noted in all the LTRs, but was particularly pronounced in GA-FeLV-B. Possible roles for this structure are discussed.

MeSH Terms
AKR murine leukemia virus/genetics Amino Acid Sequence Base Sequence Friend murine leukemia virus/genetics Genes, Viral Leukemia Virus, Feline/genetics Leukemia Virus, Murine/genetics Repetitive Sequences, Nucleic Acid Viral Envelope Proteins Viral Proteins/genetics
Chemicals
Viral Envelope Proteins Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Elder J H
Mullins J I
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.46.3.871-880.1983
Published
1983-06-00
Pages
871-80
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256562
Subset
IM
Grants
NCI NIH HHS · CA25533 · United States
NCI NIH HHS · CA25803 · United States
Databases
GENBANK
J02085
External Links
PubMed source DOI: 10.1128/JVI.46.3.871-880.1983 PMC Full Text View journal details
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