Heterogeneity of leukotriene receptors in guinea-pig trachea.

Prostaglandins ·Vol. 25 ·No. 2 ·1983-02-00 ·Pages 171-8

Krell RD, Tsai BS, Berdoulay A, Barone M, Giles RE

Abstract

The selective leukotriene (LT) antagonist FPL 55712 antagonized the contractile activity of synthetic LTD4 and E4 on guinea-pig trachea. Schild analysis of the antagonism provided evidence for two distinct receptors for LTD4: one with significantly higher affinity for FPL 55712 than the other. LTE4 appears to interact preferentially with the high affinity receptor.

MeSH Terms

Animals Chromones/pharmacology Guinea Pigs Kinetics Leukotriene E4 Male Muscle Contraction/drug effects Receptors, Cell Surface/metabolism Receptors, Leukotriene SRS-A/analogs & derivatives,metabolism,pharmacology Structure-Activity Relationship Trachea/physiology

Chemicals

Chromones Receptors, Cell Surface Receptors, Leukotriene SRS-A Leukotriene E4 FPL 55712

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Krell R D

Tsai B S

Berdoulay A

Barone M

Giles R E

Article Info

Journal

Prostaglandins

Abbr.

Prostaglandins

ISSN

0090-6980

DOI

10.1016/0090-6980(83)90102-8

Published

1983-02-00

Pages

171-8

Language

English

Region

United States

NLM ID

0320271

Subset

External Links

PubMed source DOI: 10.1016/0090-6980(83)90102-8

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Heterogeneity of leukotriene receptors in guinea-pig trachea.

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