Pharmacokinetics of sulbactam in humans.
Sulbactam, a new beta-lactamase inhibitor, has pharmacokinetic characteristics in humans similar to those of ampicillin and amoxicillin. Its half-life in humans is approximately 1 h. In a two-compartment pharmacokinetic model, the apparent volume of distribution for the central compartment is approximately 12 liters, and half of the dose is found in the central compartment in the postdistributive phase. Approximately 75% of a parenteral dose is excreted unchanged in urine. The coadministration of sulbactam with ampicillin, penicillin G, or cefoperazone has essentially no effect upon the kinetics of either the beta-lactam antibiotic or sulbactam.
16 references, click to expand
-
Penicillanic acid sulfone: an unexpected isotope effect in the interaction of 6 alpha- and 6 beta-monodeuterio and of 6,6-dideuterio derivatives with RTEM beta-lactamase from Escherichia coli.Biochemistry. 1981 Jun 23;20(13):3680-7 PMID: 6268140
-
Automated plate diffusion zone measurement and computerized data handling.Bull Parenter Drug Assoc. 1973 Jul-Aug;27(4):185-94 PMID: 4726573
-
Comparative blood levels of hetacillin, ampicillin and penicillin G.N Engl J Med. 1966 Sep 22;275(12):635-9 PMID: 5331311
-
Comparative pharmacokinetics and tissue penetration of sulbactam and ampicillin after concurrent intravenous administration.Antimicrob Agents Chemother. 1982 Apr;21(4):565-7 PMID: 6282211
-
Evaluation of gas and other chromatographic separations of indolic methyl esters.Anal Biochem. 1967 Sep;20(3):484-94 PMID: 6057638
-
Effect of probenecid on the excretion of ampicillin in human bile.Br J Pharmacol. 1973 Apr;47(4):782-6 PMID: 4723799
-
CP-45,899 in combination with penicillin or ampicillin against penicillin-resistant Staphylococcus, Haemophilus influenzae, and Bacteroides.Antimicrob Agents Chemother. 1980 Apr;17(4):615-22 PMID: 6249192
-
A sulfone beta-lactam compound which acts as a beta-lactamase inhibitor.J Antibiot (Tokyo). 1978 Dec;31(12):1238-44 PMID: 310815
-
The influence of a new benzoic acid derivative on the metabolism of paraaminosalicylic acid (PAS) and penicillin.Ann Intern Med. 1950 Jul;33(1):18-31 PMID: 15426089
-
SODIUM AMPICILLIN: ABSORPTION AND EXCRETION OF INTRAMUSCULAR AND INTRAVENOUS DOSES IN NORMAL YOUNG MEN.Am J Med Sci. 1965 Feb;249:163-71 PMID: 14257307
-
Inhibition kinetics of three R-factor-mediated beta-lactamases by a new beta-lactam sulfone (CP 45899).Biochim Biophys Acta. 1980 Feb 14;611(2):351-7 PMID: 6243991
-
The beta-lactamases of gram-negative bacteria and their possible physiological role.Adv Microb Physiol. 1973;9:31-88 PMID: 4581138
-
CP-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterization.Antimicrob Agents Chemother. 1978 Sep;14(3):414-9 PMID: 309306
-
Penicillanic acid sulfone: interaction with RTEM beta-lactamase from Escherichia coli at different pH values.Biochemistry. 1981 Jun 23;20(13):3688-95 PMID: 6268141
-
Ampicillin and hetacillin pharmacokinetics in normal and anephric subjects.Clin Pharmacol Ther. 1973 Jan-Feb;14(1):90-9 PMID: 4345622
-
Pharmacokinetics of amoxicillin.Clin Pharmacol Ther. 1974 Dec;16(6):1045-51 PMID: 4433471
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
