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PMID: 6308235 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Insensitivity of activation delays in potassium and sodium channels to heavy water in Myxicola giant axons.

The Journal of physiology ·Vol. 337 ·1983-04-00 ·Pages 173-82

Schauf CL

Abstract

Substitution of heavy water (D2O) for H2O slows the Na+ and K+ currents in Myxicola giant axons by 40-50% at 5 degrees C. In contrast, the delays in Na+ K+ activation which can be produced by hyperpolarizing pre-pulses are not affected by solvent substitution. We suggest that in the cascade of transitions leading to the opening of Na+ and K+ channels, D2O affects only the final step that establishes the aqueous pore across the membrane.

MeSH Terms
Animals Axons/metabolism,physiology Deuterium/metabolism In Vitro Techniques Ion Channels/metabolism Membrane Potentials Polychaeta Potassium/metabolism,physiology Sodium/metabolism,physiology
Chemicals
Ion Channels Sodium Deuterium Potassium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Schauf C L
References (23)
23 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1983.sp014618
Published
1983-04-00
Pages
173-82
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1199101
Subset
IM
Grants
NINDS NIH HHS · NS15741 · United States
External Links
PubMed source DOI: 10.1113/jphysiol.1983.sp014618 PMC Full Text View journal details
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