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PMID: 6316335 Published · ppublish English Journal Article

Mitochondrial DNA heteroplasmy in Drosophila mauritiana.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 22 ·1983-11-00 ·Pages 6942-6

Solignac M, Monnerot M, Mounolou JC

Abstract

Mitochondrial DNA extracted from an isofemale strain of Drosophila mauritiana (subgroup melanogaster) appeared to be heterogeneous in size. A short genome [S; 18,500 base pairs (bp)] and a longer one (L; 19,000 bp) coexist in the preparation. The additional 500 bp have been located within the A+T-rich region. Hpa I digest patterns suggest that the S genome may carry a duplication of a 500-bp sequence including an Hpa I site and that the L genome may carry a triplication of the same sequence. At the 30th generation of the isofemale strain, 60 female genotypes were examined individually. Half of the files were pure either for the S or the L DNA. The remaining 50% exhibited various degrees of heteroplasmy for the two DNA types. Among metazoan animals, this D. mauritiana strain offers an exceptional situation with regard to the number of individuals heterogeneous for mtDNA and the relative stability of heteroplasmy through generations.

MeSH Terms
Animals Base Composition Base Sequence DNA Restriction Enzymes DNA, Mitochondrial/genetics,isolation & purification Drosophila/genetics Molecular Weight
Chemicals
DNA, Mitochondrial DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Solignac M
Monnerot M
Mounolou J C
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29 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.22.6942
Published
1983-11-00
Pages
6942-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC390102
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.80.22.6942 PMC Full Text View journal details
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