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PMID: 6317898 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Amplification and novel locations of endogenous mouse mammary tumor virus genomes in mouse T-cell lymphomas.

Journal of virology ·Vol. 49 ·No. 1 ·1984-01-00 ·Pages 92-101

Dudley J, Risser R

Abstract

Endogenous mouse mammary tumor virus genomes are amplified and located in novel cell DNA sequences in many mouse T-cell lymphomas. Transplanted tumors recovered from the same mouse strain and shown to be of independent origin by chromosomal analysis, by the presence of JH immunoglobulin gene rearrangements, or by the integration patterns of exogenous Moloney MuLV genomes frequently showed similar patterns of novel mouse mammary tumor virus-containing cell DNA fragments. This process of amplification and relocation can occur within a limited number of cell generations and in C57BL/6 mice does not lead to the synthesis of mature virus-encoded proteins. In some instances, amplified mouse mammary tumor virus genomes contained novel restriction cleavage sites in the gag-pol region. The restricted time course of occurrence, lack of synthesis of mature virion proteins, and apparent site specificity indicate that this process of retrovirus amplification differs significantly from virus replication after exogenous infection.

MeSH Terms
Animals Cell Transformation, Viral Chromosome Mapping DNA, Viral/genetics Gene Amplification Gene Expression Regulation Genes, Viral Lymphoma/genetics Mammary Tumor Virus, Mouse/genetics Mice T-Lymphocytes/microbiology Viral Proteins/genetics
Chemicals
DNA, Viral Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dudley J
Risser R
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.49.1.92-101.1984
Published
1984-01-00
Pages
92-101
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255429
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.49.1.92-101.1984 PMC Full Text View journal details
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