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PMID: 6318562 Published · ppublish English Journal Article

Immunoperoxidase demonstration of a new muscle protein (Z-protein) in myogenic tumors as a diagnostic aid.

The American journal of pathology ·Vol. 114 ·No. 1 ·1984-01-00 ·Pages 164-70

Mukai M, Iri H, Torikata C, Kageyama K, Morikawa Y, Shimizu K

Abstract

Z-protein, a new muscle protein with a molecular weight of 55,000 daltons recently discovered in Japan, is an excellent marker for muscle differentiation in paraffin sections. Positive staining by a peroxidase-antiperoxidase technique for detection of intracellular Z-protein was observed in 2 of 2 cardiac rhabdomyomas, 5 of 5 leiomyomas, 9 of 10 leiomyosarcomas, and in 15 of 18 rhabdomyosarcomas including 5 of 5 of the pleomorphic type, 7 of 9 of the embryonal type, and 3 of 4 of the alveolar type. Other types of tumors (77 cases) that sometimes mimic myogenic tumors on histologic examination gave negative results. The immunoperoxidase method for detection of intracellular Z-protein is of use in distinguishing myogenic tumors from other types of tumors.

MeSH Terms
Adolescent Adult Aged Animals Carrier Proteins/immunology Child Child, Preschool Diagnosis, Differential Fatty Acid-Binding Proteins Female Histiocytoma, Benign Fibrous/diagnosis Histocytochemistry Humans Immunoenzyme Techniques Infant, Newborn Leiomyoma/diagnosis,metabolism Lymphoma/diagnosis Male Middle Aged Muscles/analysis Neoplasms, Muscle Tissue/diagnosis,metabolism Rhabdomyosarcoma/diagnosis,metabolism
Chemicals
Carrier Proteins Fatty Acid-Binding Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Mukai M
Iri H
Torikata C
Kageyama K
Morikawa Y
Shimizu K
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20 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1984-01-00
Pages
164-70
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1900406
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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